import cv2

method = cv2.TM_SQDIFF_NORMED
small = cv2.imread('small.png')
large = cv2.imread('large.png')
result = cv2.matchTemplate(small,large,method)
mn,_,mnLoc,_=cv2.minMaxLoc(result)
MPx,MPy = mnLoc
trows,tcols = small.shape[:2]
cv2.rectangle(large,(MPx,MPy),(MPx+tcols,MPy+trows),(0,0,255),2)
cv2.imshow('output',large)
cv2.waitKey(0)